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KMID : 0939920020340050382
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대한암학회지
2002 Volume.34 No. 5 p.382 ~ p.387
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Salvage Treatment for Advanced Gastric Cancer Using FEP (5-FU, Etoposide, Cisplatin) Combination Chemotherapy
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Chung Je-Hyuk
Bae Yee-Zee
Kim Sung-Hyun
Moon Chang-Hoon
Chung Jun-Young
Kwon Hyuk-Chan
Kim Jae-Seok
Kim Hyo-Jin
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Abstract
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Purpose: There is no effective treatment for patients with advanced gastric cancer having failed to respond to first line chemotherapy. The aim of this study was to evaluate the therapeutic activity, and safety, of a FEP regimen in patients
with
a recurrence of, or metastatic, gastric cancer that had been unresponsive to primary chemotherapy.
Materials and Methods: Recurred or metastatic gastric cancer patients that did not respond to a 5-fluorouracil based regimen were entered into this trial. The patients were treated with FEP (5-FU, etoposide and cisplatin) as salvage
chemotherapy.
The treatment regimen was 5-FU (900 ㎎/㎡/day) by continuous infusion for 3 days, etoposide (90 ㎎/㎡/day) on days 1, 2 and 3, and cisplatin (60 ㎎/㎡/day) on day 2. This treatment was repeated every 3 weeks.
Results: Between December 1997 and October 2001, 28 patients were enrolled to the study. The response rate was 32.1% (95% CI 15.5∼57.8%). The median times to progression and survival duration were 23∼33 weeks, respectively. Among a total
of 187
cycles of chemotherapy, the grade 3 and 4 hematological toxicities were leukopenia (6.4%), thrombocytopenia (1.6%), and grade 3 non-hematological side effects of nausea/vomiting (17.9%).
Conclusion: FEP combination chemotherapy seems to be an effective treatment regimen for gastric cancer as salvage chemotherapy. To confirm these results, large scale of clinical trials will be required.
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KEYWORD
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Stomach neoplasms, Salvage therapy, 5-FU, Etoposide, Cisplatin
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